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In long term or high dose testosterone use the testes can actually cease production or can actually atrophy which can lead to a long delay in the testes beginning manufacturing testosterone naturally. In short, testosterone may decrease while estrogen may increase. Testosterone also affects a variety of organs. Testosterone can inhibit production of the gonadal sex hormones (testosterone, estrogen) and may also affect the production of certain hormone-sensitive immune response molecules such as the immune related factor interleukin 6 (IL-6) and interleukin 10 (IL-10). The testicles also produce another hormone-sensitive messenger protein, adiponectin. And the testes are capable of stimulating the expression of the hormone corticosterone by enhancing the production of cortisol (which can also produce the symptoms of stress). This may be due to the testosterone having a strong effect on hormones that signal stress or stress-induced immune responses (such as IL-6). Testosterone also causes certain cancers. The hormone testosterone also affects the body's ability to produce thyroid hormones. In men, testosterone can alter the balance of the thyroid cells at a cellular level. This can cause symptoms such as excessive sweating or hyperthyroidism. The testosterone produced in the testes during long term or high stress hormone use also affects men's bone density – resulting in a decrease in testosterone's ability to maintain bone density. This can also occur in men who are exposed to high levels of testosterone in utero or when they take anabolic steroids. If the testosterone exposure is greater, increased bone density may be less likely to occur. In other words, bone density can be increased in men with testosterone exposure and decreased in those exposed to different types of testosterone (steroids and estrogens). Testosterone and the Aging Brain The aging brain can impair performance on some cognitive tasks for up to a decade and reduce the performance of many people who take anabolic steroids in high dosages, as well as the performance of those who take placebos. Although the exact effect on cognitive abilities is a matter of dispute among researchers, a general trend suggests that those taking testosterone may take less, or even stop performing certain cognitive tasks. This is not to say that taking testosterone does not have some effect. There are many reasons to choose which type of testosterone you use, and what dosages are appropriate, but it certainly helps to do some research if you are a male who has ever taken anabolic steroids. A number of neurological conditions commonly associated with a reduced ability to perform cognitive tasks include depression, memory loss, and epilepsy. Men who take testosterone tend to have lower odds of being diagnosed with these conditions than those taking place Related Article:

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